(Pyr³)-Amyloid β-Protein (3-42)

Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

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Product Number: 4029424

CAS Number: 183449-57-2

CHF 355.20 – CHF 540.40

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Product Description

(Pyr³)-Amyloid β-Protein (3-42) was found to be the predominant amyloid β-peptide structure deposited in human brain of Alzheimer’s disease and Down’s syndrome patients. Therefore, (Pyr³)-Aβ (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits. Nussbaum et al. studies the Prion-like behaviour and tau-dependent cytotoxicity of the truncated Aβ sequence.

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Amyloid Beta Peptides & Alzheimer's Disease
Functional analysis of GnRH receptor ligand binding using biotinylated GnRH derivatives.

B.Byrne et al., Mol. Cell. Endocrinol., 144, 11 (1998)

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model.

O.Wirths et al., Acta Neuropathol., 118, 487 (2009)

On the seeding and oligomerization of pGlu-amyloid peptides (in vitro).

S.Schilling et al., Biochemistry, 45, 12393 (2006)

Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons.

K.Shirotani et al., Neurosci. Lett., 327, 25 (2002)

Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain.

T.C.Saido et al., Neurosci. Lett., 215, 173 (1996)

Presenilin-1 mutations in Alzheimer's disease.

C.Russo et al., Nature, 405, 531 (2000)

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.

J.M.Nussbaum et al., Nature, 485, 651 (2012)

Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain.

Y.Harigaya et al., Biochem. Biophys. Res. Commun., 276, 422 (2000)

Quantification of modified amyloid beta peptides in Alzheimer disease and Down syndrome brains.

R.Hosoda et al., J. Neuropathol. Exp. Neurol., 57, 1089 (1998)

Pyroglutamate-modified amyloid beta-peptides--AbetaN3(pE)--strongly affect cultured neuron and astrocyte survival.

C.Russo et al., J. Neurochem., 82, 1480 (2002)

Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains.

C.Russo et al., FEBS Lett., 409, 411 (1997)

Salt form: Ammonium

Molecular weight: 4309.92

Chemical Formula: C₁₉₆H₂₉₉N₅₃O₅₅S

Storage Temperature: < -15°C

Synonyms: (Glp3) β-Amyloid (3-42)

One Letter code: pEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

Source: Synthetic

Old Product Number: H-4796

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