(Gly⁵,Thr⁷,Ser⁹)-Oxytocin

H-Cys-Tyr-Ile-Gln-Gly-Cys-Thr-Leu-Ser-NH₂ (Disulfide bond)

Product Number: 4144391

€ 224.70

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Product Description

The cyclopeptide kB7-OT1 was designed using the kalata B7 loop 3 as template. The oxytocin analog turned out to be a selective agonist at the oxytocin receptor capable to intact human myometrium in the submicromolar range, neglecting other subtype related receptors (i.e. V1a, V1b and V2 receptors) at concentrations higher than 10 μM.

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Conopressin-T from Conus Tulipa reveals an antagonist switch in vasopressin-like peptides.

S.Dutertre et al., J. Biol. Chem., 283, 7100 (2008)

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design.

J.Koehbach et al., Proc. Natl. Acad. Sci. USA, 110, 21183 (2013)

Salt form: Trifluoroacetate

Molecular weight: 984.15

Chemical Formula: C₄₁H₆₅N₁₁O₁₃S₂

Storage Temperature: < -15°C

Synonyms: kB7-OT

One Letter code: CYIQGCTLS-NH₂

Source: Synthetic

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