(d(CH₂)₅¹,D-Ile²,Ile⁴,Arg⁸,Tyr⁹)-Vasopressin

β-Mercapto-β,β-cyclopentamethylene-propionyl-D-Ile-Phe-Ile-Asn-Cys-Pro-Arg-Tyr-NH₂ (Disulfide bond)

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Product Number: 4144389

CAS Number: 114438-90-3

€ 224.70

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Product Description

AVP antagonist specifically targeting the rat V2 receptor. Data obtained by Cotte et al. indicate that the type of amino acid in position 2 controls the rat versus human selectivity in AVP analogs.

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Development of a human vasopressin V 1a-receptor antagonist from an evolutionary-related insect neuropeptide.

M.G.Di Giglio et al., Sci. Rep., 7, 41002 (2017)

Identification of residues responsible for the selective binding of peptide antagonists and agonists in the V2 vasopressin receptor.

N.Cotte et al., J. Biol. Chem., 273, 29462 (1998)

Potent V2 vasopressin antagonists with structural changes at their C-terminals.

W.H.Sawyer, Peptides, 9, 157 (1988)

The D136A Mutation of the V2 vasopressin receptor induces a constitutive activity which permits discrimination between antagonists with partial agonist and inverse agonist activities.

D.Morin et al., FEBS Lett., 441, 470 (1998)

Salt form: Trifluoroacetate

Molecular weight: 1178.47

Chemical Formula: C₅₆H₈₃N₁₃O₁₁S₂

Storage Temperature: < -15°C

Synonyms: d(CH2)5[D-Ile2,Ile4,Tyr9]-AVP

Source: Synthetic

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