Q-Peptide

This sequence belongs to integrin motifs in the fibrinogen-like (fbg-lk) domain of Ang1 and Ang2 that were found conserved among mouse, rat, human, and other species. The same or similar amino acid sequence exists in human Ang1 and 2, mouse Ang1 to 3 and 5, pig Ang1 and 2, chicken Ang2 isoforms A and B, zebrafish Ang1 to 3, C. elegans angiopoietin (Ang)-related protein, human Angptl1 to 6, mouse Angptl3, and yellow fever mosquito Ang-related protein. Dallabrida and coworkers propose that select myocyte integrins adhere to Ang1 and Ang2 via the fbg-lk domain, possibly at or including the sequence QHREDGS.