(Arg¹³)-Amyloid β-Protein (1-40)

H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

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Product Number: 4095736

CAS Number: 1816939-33-9

€ 138 – € 229

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Product Description

H13R, a mutation in the metal-binding region of Abeta reduces its copper-mediated toxicity. The native rodent sequence containing an arginine at this position is more tolerant to metals than the human amyloid peptide.

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Amyloid Beta Peptides & Alzheimer's Disease

Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abeta1-40 fibrillogenesis.

D.J.Gordon et al., J. Pept. Res., 60, 37 (2002)

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

D.P.Smith et al., J. Biol. Chem., 281, 15145 (2006)

HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons.

J.F.Poduslo et al., PLoS One, 5, e8813 (2010)

Salt form: Trifluoroacetate

Molecular weight: 4348.91

Chemical Formula: C₁₉₄H₃₀₀N₅₄O₅₈S

Storage Temperature: < -15°C

Synonyms: [Arg13] β-Amyloid (1-40)

One Letter code: DAEFRHDSGYEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV

Source: Synthetic

Old Product Number: H-7662

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