Phalloidin

Cyclo(-Ala-D-Thr-Cys-cis-Hyp-Ala-Trp-(4R)-4,5-dihydroxy-Leu) (Sulfide bond between Cys and indol-2-yl)

Product Number: 4095642

CAS Number: 17466-45-4

CHF 185.10

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Product Description

A bicyclic 7 amino acid peptide toxin originally isolated from the poisonous mushroom Amanita phalloides. Phalloidin binds specifically to the interface between F-actin subunits.

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Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein.

D.B.Glass et al., J. Biol. Chem., 264, 8802 (1989)

Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms.

J.D.Walton et al., Biopolymers, 94, 659 (2010)

The toxic peptides from Amanita mushrooms.

T.Wieland, Int. J. Pept. Protein Res., 22, 257 (1983)

Visualising the actin cytoskeleton.

J.Small et al., Microsc. Res. Tech., 47, 3 (1999)

Salt form: Trifluoroacetate

Molecular weight: 788.87

Chemical Formula: C₃₅H₄₈N₈O₁₁S

Storage Temperature: -20 ± 5 °C

Synonyms: Bicyclic(Ala-DThr-Cys-cis-4-hydroxy-Pro-Ala-2-mercapto-Trp-4,5-dihydroxy-Leu)(S-3→6)

Source: Synthetic

Old Product Number: H-7598

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