1,3-Bis-(Z-Leu-Leu)-diaminoacetone

Z-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z

Product Number: 4095624

CAS Number: 313664-40-3

€ 51.40

Custom/Bulk Quote
Pack size available

5mg
Please select pack size:
Add to your inquiry

Product Description

(Z-LL)₂ Ketone, cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC₅₀ ca. 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasome.

ADS
Example ADS
ADS lookup
ADS Lookup
MSDS
MSDS
MSDS lookup
MSDS Lookup
Amyloid Beta Peptides & Alzheimer's Disease
Substrate specificity of human pancreatic elastase 2.

E.G.Del Mar et al., Biochemistry, 19, 468 (1980)

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor.

A.Weihofen et al., J. Biol. Chem., 30951, 30951 (2000)

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors.

A.Weihofen et al., J. Biol. Chem., 278, 16528 (2003)

Molecular weight: 809

Sum Formula: C₄₃H₆₄N₆O₉

Storage Temperature: < -15°C

Synonyms: (Z-LL)2 Ketone

One Letter code: (Z-LL)₂

Source: Synthetic

Old Product Number: C-4275

Inhibitors
Signal Peptide Peptidase

Country

Inquiry List

No products in the list

Discounts

SPECIAL
OFFERS

FAQ's

FAQs

ADS lookup

ADS Lookup

MSDS lookup

MSDS Lookup

Knowledge Center

Knowledge
Center