Cilengitide

Cyclo(-Arg-Gly-Asp-D-Phe-N-Me-Val)

Product Number: 4060586

CAS Number: 188968-51-6

€ 65.30 – € 247.20

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Product Description

The cyclic RGD peptide cilengitide is a potential cancer drug. Cilengitide is under investigation for the treatment of glioblastoma, where it may act by inhibiting angiogenesis, and influencing tumor invasion and proliferation.

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Peptides in cancer research
Pseudin-2: an antimicrobial peptide with low hemolytic activity from the skin of the paradoxical frog.

L.Olson III et al., Biochem. Biophys. Res. Commun., 288, 1001 (2001)

Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts

P.Burker et al., Cancer Res., 62, 4263 (2002)

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

M.M.Dechantsreiter et al., J. Med. Chem., 42, 3033 (1999)

Salt form: Trifluoroacetate

Molecular weight: 588.66

Chemical Formula: C₂₇H₄₀N₈O₇

Storage Temperature: < -15°C

Synonyms: EMD 121974

One Letter code: c(RGDf(Me)V)

Source: Synthetic

Old Product Number: H-8174

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