SDF-1α (human)

H-Lys-Pro-Val-Ser-Leu-Ser-Tyr-Arg-Cys-Pro-Cys-Arg-Phe-Phe-Glu-Ser-His-Val-Ala-Arg-Ala-Asn-Val-Lys-His-Leu-Lys-Ile-Leu-Asn-Thr-Pro-Asn-Cys-Ala-Leu-Gln-Ile-Val-Ala-Arg-Leu-Lys-Asn-Asn-Asn-Arg-Gln-Val-Cys-Ile-Asp-Pro-Lys-Leu-Lys-Trp-Ile-Gln-Glu-Tyr-Leu-Glu-Lys-Ala-Leu-Asn-Lys-OH (Disulfide bonds between Cys⁹ and Cys³⁴/Cys¹¹ and Cys⁵⁰)

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Product Number: 4051449

CAS Number: 1268129-65-2

€ 160.50 – € 643.10

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Product Description

Synthetically produced, contains BSA (low levels of endotoxins) in a ratio of 1:50. Multifunctional cytokine that signals through CXCR4. SDF-1α is involved in several pathological conditions such as rheumatoid arthritis, pulmonary fibrosis, metastasis and leukemia cell progression. SDF-1α-dependent internalization of the CXCR4 HIV coreceptor contributes to inhibition of HIV replication

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Peptides in cancer research
Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity.

M.De La Luz Sierra et al., Blood, 103, 2452 (2004)

Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis.

J.Xu et al., Am. J. Respir. Cell Mol. Biol., 37, 291 (2007)

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication.

A.Amara et al., J. Exp. Med., 186, 139 (1997)

Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells.

A.Kalinkovich et al., Cancer Res., 66, 11013 (2006)

Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients.

T.Iwamoto et al., FEBS J., 275, 4448 (2008)

Involvement of chemokine receptors in breast cancer metastasis.

A.Müller et al., Nature, 410, 50 (2001)

Salt form: Trifluoroacetate

Molecular weight: 7959.43

Chemical Formula: C₃₅₆H₅₇₈N₁₀₆O₉₃S₄

Storage Temperature: < -15°C

Synonyms: Stromal Cell-Derived Factor-1α (human)

One Letter code: KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK

Source: Synthetic

Old Product Number: H-6394

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