Acetyl-(D-Arg¹⁰,Cys¹¹,D-Phe¹⁴,Cys¹⁷)-β-MSH (10-17) amide

Ac-D-Arg-Cys-Glu-His-D-Phe-Arg-Trp-Cys-NH₂ (Disulfide bond)

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Product Number: 4049312

CAS Number: 819048-44-7

 107 428

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Product Description

Highly potent and selective β-MSH-derived melanocortin-4 receptor (MC-4R) agonist with sub-nanomolar potency. The binding affinities for human MC-4R, MC-1R, MC-3R and MC-5R were 0.55 ± 0.06, 16.78 ± 1.53, 56.79 ± 4.66, and < 500 nM, respectively. Daily subcutaneous injection of H-6268 to diet-induced obese rats over a period of 14 days demonstrated an effect on reduction of fat mass.

H.Hosoda et al., Biochem. Biophys. Res. Commun., 279, 909 (2000)

Salt form: Trifluoroacetate

Molecular weight: 1175.36

Chemical Formula: C₅₁H₇₀N₁₈O₁₁S₂

Storage Temperature: < -15°C

One Letter code: Ac-rCEHfRWC-NH₂

Source: Synthetic

Old Product Number: H-6268

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