Octreotide

H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol (Disulfide bond)

Product Number: 4042822

CAS Number: 79517-01-4

CHF 89.90 – CHF 360.60

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Product Description

Octreotide is a longer acting synthetic octapeptide analog of the naturally occurring hormone somatostatin. It inhibits the secretion of gastro-entero-pancreatic peptide hormones and the release of growth hormones. Melacini et al. studied the conformation of the peptide in solution by NMR. CAS Number (net): 83150-76-9.

Peptides in cancer research

Identification of a MHC class II-restricted human gp100 epitope using DR4-IE transgenic mice.

C.E.Touloukian et al., J. Immunol., 164, 3535 (2000)

Multiconformational NMR analysis of sandostatin (octreotide): equilibrium between beta-sheet and partially helical structures.

G.Melacini et al., Biochemistry, 36, 1233 (1997)

Octreotide.

S.W.Lamberts et al., N. Engl. J. Med., 334, 246 (1996)

Intrarenal octreotide treatment prevents sodium retention in liver cirrhotic rats: evidence for direct effects within the thick ascending limb of Henle's loop.

T.E.Jonassen et al., Am. J. Physiol. Renal Physiol., 291, F537 (2006)

Octreotide and the mTOR inhibitor RAD001 (everolimus) block proliferation and interact with the Akt-mTOR-p70S6K pathway in a neuro-endocrine tumour cell Line.

S.Grozinsky-Glasberg et al., Neuroendocrinology, 87, 168 (2008)

Salt form: Acetate

Molecular weight: 1019.26

Chemical Formula: C₄₉H₆₆N₁₀O₁₀S₂

Storage Temperature: < -15°C

Synonyms: (D-Phe⁵,Cys⁶·¹¹,D-Trp⁸,L-Threoninol¹²)-Somatostatin-14 (5-12)

Source: Synthetic

Old Product Number: H-5972

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