(Met(O)³⁵)-Amyloid β-Protein (1-42)

H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met(O)-Val-Gly-Gly-Val-Val-Ile-Ala-OH

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Product Number: 4041297

CAS Number: 1802086-68-5

€ 312.40

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Product Description

(Met(O)³⁵)-Amyloid β-protein (1-42), in contrast to Aβ 1-42, has been shown to be non-toxic to 9-11 day-old rat embryonic hippocampal neuronal cultures and not to produce any protein oxidation. It has also been demonstrated that fibril formation is not affected by Met(O)³⁵.

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Amyloid Beta Peptides & Alzheimer's Disease

Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.

K.Takeda et al., FASEB J., 18, 755 (2004)

The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity.

D.A.Butterfield and D.Boyd-Kimball, Biochim. Biophys. Acta, 1703, 149 (2005)

Role of methionine 35 in the intracellular Ca2+ homeostasis dysregulation and Ca2+-dependent apoptosis induced by amyloid beta-peptide in human neuroblastoma IMR32 cells.

R.Piacentini et al., J. Neurochem., 107, 1070 (2008)

Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide 1-42.

D.A.Butterfield and J.Kanski, Peptides, 23, 1299 (2002)

The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity.

D.A.Butterfield and D.Boyd-Kimball, Biochim. Biophys. Acta, 1703, 149 (2005)

Role of methionine 35 in the intracellular Ca2+ homeostasis dysregulation and Ca2+-dependent apoptosis induced by amyloid beta-peptide in human neuroblastoma IMR32 cells.

R.Piacentini et al., J. Neurochem., 107, 1070 (2008)

Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta(1--42) and A beta(25--35).

S.Varadarajan et al., J. Am. Chem. Soc., 123, 5625 (2001)

Molecular weight: 4530.1

Chemical Formula: C₂₀₃H₃₁₁N₅₅O₆₁S

Storage Temperature: < -15°C

Synonyms: Amyloid β-Protein (1-42) sulfoxide

Source: Synthetic

Old Product Number: H-5888

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