Endothelin-1 (human, bovine, dog, mouse, porcine, rat)

H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bonds between Cys¹ and Cys¹⁵/Cys³ and Cys¹¹)

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Product Number: 4040254

CAS Number: 117399-94-7

€ 680.50 – € 2,281.20

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Product Description

Endothelin-1, a 21-amino acid peptide from vascular endothelial cells of different mammalian species, is one of the most potent vasoconstrictors. ET-1 exerts a wide variety of effects on both vascular and non-vascular (e.g. heart, lung, brain) tissues. Toxic peptides from a snake venom, the sarafotoxins, show structural and functional homology to ET-1. The role of ET-1 in clinical hypertension has been reviewed by Dhaun et al. and by Sreenivas and Oparil. ET-1 plays a central role in lung fibrosis.

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Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.

K.Lewis et al., Proc. Natl. Acad. Sci. USA, 98, 7570 (2001)

Endothelin, a novel endothelium-derived peptide. Pharmacological activities, regulation and possible roles in cardiovascular control.

M.Yanagisawa and T.Masaki, Biochem. Pharmacol., 38, 1877 (1989)

Potential role of endothelin-1 in pulmonary fibrosis: from the bench to the clinic.

S.Sreenivas and S.Oparil, Clin. Hemorheol. Microcirc., 31, 157 (2007)

The discovery, the present state, and the future prospects of endothelin.

B.Ross et al., Am. J. Respir. Cell Mol. Biol., 42, 16 (2010)

Endothelin: a new cardiovascular regulatory peptide.

T.Masaki, J. Cardiovasc. Pharmacol., 13, (Suppl.5), S1 (1989)

Peptide vasoconstrictors, vessel structure, and vascular smooth-muscle proliferation.

A.Lerman et al., Mayo Clin. Proc., 65, 1441 (1990)

Role of endothelin-1 in clinical hypertension: 20 years on.

A.W.A.Hahn et al., J. Cardiovasc. Pharmacol., 22 (Suppl.5), S37 (1993)

Peptide vasoconstrictors, vessel structure, and vascular smooth-muscle proliferation.

N.Dhaun et al., Hypertension, 52, 452 (2008)

A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

A.W.A.Hahn et al., J. Cardiovasc. Pharmacol., 22 (Suppl.5), S37 (1993)

Molecular biology and biochemistry of the endothelins.

M.Yanagisawa et al., Nature, 332, 411 (1988)

M.Yanagisawa and T.Masaki, Trends Pharmacol. Sci., 10, 374 (1989)

Salt form: Acetate

Molecular weight: 2491.94

Chemical Formula: C₁₀₉H₁₅₉N₂₅O₃₂S₅

Storage Temperature: < -15°C

Synonyms: ET-1 (human, bovine, dog, mouse, porcine, rat)

One Letter code: CSCSSLMDKECVYFCHLDIIW

Source: Synthetic

Old Product Number: H-6995

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