(Gly¹⁴)-Humanin (human)

H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH

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Product Number: 4038277

CAS Number: 330936-70-4

€ 169.10 – € 290

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Product Description

S14G-Humanin (HNG) is a more potent neuroprotective factor than native humanin. In middle-aged APPswe/PS1dE9 mice, the mutant peptide improved cognitive deficits and reduced amyloid pathology. S14G-Humanin inhibited Aβ 1-42 fibril formation, disaggregates preformed fibrils, and protects against Abeta-induced cytotoxicity in vitro.

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Amyloid Beta Peptides & Alzheimer's Disease
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.

Y.Hashimoto et al., Proc. Natl. Acad. Sci. USA, 98, 6336 (2001)

S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice.

W.Zhang et al., Pharmacol. Biochem. Behav., 100, 361 (2012)

S14G-humanin inhibits Aβ1-42 fibril formation, disaggregates preformed fibrils, and protects against Aβ-induced cytotoxicity in vitro.

W.Zhang et al., J. Pept. Sci., 19, 159 (2013)

A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.

T.Niikura et al., PLoS One, 6, e16259 (2011)

S14G-Humanin ameliorates Abeta25-35-induced behavioral deficits by reducing neuroinflammatory responses and apoptosis in mice.

J.Miao et al., Neuropeptides, 42, 557 (2008)

Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties.

B.Zapala et al., Pharmacol. Rep., 62, 767 (2010)

Salt form: Trifluoroacetate

Molecular weight: 2657.25

Chemical Formula: C₁₁₈H₂₀₂N₃₄O₃₁S₂

Storage Temperature: < -15°C

Synonyms: S14G-Humanin (human)

One Letter code: MAPRGFSCLLLLTGEIDLPVKRRA

Source: Synthetic

Old Product Number: H-5576

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