(Pyr¹¹)-Amyloid β-Protein (11-40)

Pyr-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

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Product Number: 4037661

CAS Number: 192377-94-9

€ 88.80 – € 157.30

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Product Description

pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV, the N-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with a pyroglutamate (Pyr) residue at position 11 was used in experiments studying the generality of fibrillogenesis-related helix formation. Comparing the fibrillogenesis kinetics of many of the most important clinically relevant amyloid β-protein alloforms it could be observed that among these peptides (Pyr¹¹)-amyloid β-protein (11-40) exhibited the greatest retardation of fibrillization rate.

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Amyloid Beta Peptides & Alzheimer's Disease
Metal switch for amyloid formation: insight into the structure of the nucleus.

D.M.Morgan et al., J. Am. Chem. Soc., 124, 12644 (2002)

Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains.

C.Russo et al., FEBS Lett., 409, 411 (1997)

Pyroglutamate-Modified Amyloid Beta Peptides: Emerging Targets for Alzheimer´s Disease Immunotherapy.

R.Perez-Garmendia and G.Gevorkian, Curr. Neuropharmacol., 11, 491 (2013)

A beta peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture.

S.S.Mok et al., J. Neurosci. Res., 61, 449 (2000)

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis.

M.D.Kirkitadze et al., J. Mol. Biol., 312, 1103 (2001)

The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta.

W.He and C.J.Barrow, Biochemistry, 38, 10871 (1999)

Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains.

C.Russo et al., FEBS Lett., 409, 411 (1997)

Molecular weight: 3133.67

Chemical Formula: C₁₄₃H₂₂₆N₃₈O₃₉S

Storage Temperature: < -15°C

One Letter code: pEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV

Source: Synthetic

Old Product Number: H-6382

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