Fmoc-Asp(OtBu)-(Hmb)Gly-OH
CHF 326.40 – CHF 1,236.90
Pack size available | 1g, 5g |
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Product Description
Aspartimide formation of the highly base-labile Asp-Gly motif during Fmoc-SPPS may be completely suppressed by coupling this Hmb-protected dipeptide derivative. Additionally, Hmb prevents aggregation of the growing peptide chain as efficiently as the incorporation of a pseudoproline moiety. O-Acylation renders the Hmb moiety acid-stable facilitating the purification of peptides prone to form aggregates. The acyl group can be removed with hydrazine hydrate in DMF (cf. Quibell).