Z-Leu-Arg-AMC

Z-Leu-Arg-AMC

Product Number: 4034611

CAS Number: 156192-32-4

€ 312.40 – € 1,248.70

Custom/Bulk Quote

Pack size available	50mg, 250mg

Please select pack size:

Pack size available

Clear

Add to your inquiry

Product Description

Z-LR-AMC, a fluorogenic substrate for cathepsin L, S, and V, human tissue kallikrein, and the falcipains I – III. Z-LR-AMC is the preferred substrate of falcipain II, a hemoglobin-degrading cysteine protease from Plasmodium falciparum, one of the most promising targets for antimalarial drug design. Z-LR-AMC is used for assaying cathepsin K, an enzyme involved in osteoclastic bone resorption.

ADS

ADS lookup

MSDS

MSDS lookup

The NPY Y1 receptor antagonist BIBP 3226 blocks NPY induced feeding via a non-specific mechanism.

D.G.A.Morgan et al., Regul. Pept., 75-76, 377 (1998)

Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.

T.Cheng et al., J. Biol. Chem., 281, 15893 (2006)

A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2.

A.Singh et al., Protein Eng. Des. Sel., 20, 171 (2007)

Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids.

C.Serveau-Avesque et al., Biol. Cell, 98, 15 (2006)

Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum.

P.S.Sijwali and P.J.Rosenthal, Proc. Natl. Acad. Sci. USA, 101, 4384 (2004)

Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents.

N.Micale et al., J. Med. Chem., 49, 3064 (2006)

Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences.

M.Debela et al., J. Biol. Chem., 281, 25678 (2006)

Salt form: Hydrochloride

Molecular weight: 578.67

Sum Formula: C₃₀H₃₈N₆O₆

Storage Temperature: < -15°C

One Letter code: Z-LR-AMC

Source: Synthetic

Old Product Number: I-1960

Substrates
Tissue Kallikrein
Cathepsin S
Cathepsin L
Falcipain I
Falcipain II
Cathepsin K

Country

Inquiry List