α-CGRP (8-37) (mouse, rat)

H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH₂

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Product Number: 4034544

CAS Number: 129121-73-9

€ 267.50 – € 1,071.10

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Product Description

α-CGRP (8-37), a competitive CGRP1 receptor antagonist, exhibited hypothermic and antinociceptive effects. CGRP-I (8-37) antagonized the effects of amylin and amylin (1-8) on osteoblasts but was substantially less potent in this regard than amylin (8-37). Furthermore, it inhibited the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats.

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Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney.

P.J.Harris et al., Am. J. Physiol., 272, F13 (1997)

Dissociation of the effects of amylin on osteoblast proliferation and bone resorption.

J.Cornish et al., Am. J. Physiol., 274, E827 (1998)

Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat.

H.C.Champion et al., Am. J. Physiol., 272, R234 (1997)

Calcitonin gene-related peptide 8-37 inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats.

L.C.Yu et al., Regul. Pept., 83, 21 (1999)

The hypothermic and antinociceptive effects of intrathecal injection of CGRP (8-37) in mice.

M.A.Saxen et al., Life Sci., 55, 1665 (1994)

Receptor subtypes mediating renal actions of calcitonin gene-related peptide.

A.M.Elhawary et al., Eur. J. Pharmacol., 286, 255 (1995)

Salt form: Trifluoroacetate

Molecular weight: 3127.56

Chemical Formula: C₁₃₈H₂₂₄N₄₂O₄₁

Storage Temperature: < -15°C

Synonyms: Calcitonin Gene-Related Peptide I (8-37) (mouse, rat)

One Letter code: VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH₂

Source: Synthetic

Old Product Number: H-4924

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