Boc-Lys(Ac)-AMC

Boc-Lys(Ac)-AMC

Product Number: 4033972

CAS Number: 233691-67-3

€ 356.30

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Product Description

Often used histone deacetylase (HDAC) substrate. Hoffmann et al. and Wegener et al. employed it in assays for screening compounds for inhibitory activity. Ciossek et al. developed a cellular HDAC assay suitable for robotic screening. HDAC cleavage yields Boc-Lys-AMC.

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Efficient expression of tyrosine-sulfated proteins in E. coli using an expanded genetic code.

C.C.Liu et al., Nat. Protoc., 4, 1784 (2009)

A homogeneous cellular histone deacetylase assay suitable for compound profiling and robotic screening.

T.Ciossek et al., Anal. Biochem., 372, 72 (2008)

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon.

M.Waldecker et al., J. Nutr. Biochem., 19, 587 (2008)

Identification of novel small-molecule histone deacetylase inhibitors by medium-throughput screening using a fluorigenic assay.

D.Wegener et al., Biochem. J., 413, 143 (2008)

Molecular weight: 445.52

Sum Formula: C₂₃H₃₁N₃O₆

Storage Temperature: < -15°C

Old Product Number: I-1875

Substrates
Histone Deacetylase

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