Z-Ala-Ala-Asn-AMC

Z-Ala-Ala-Asn-AMC

Product Number: 4033201

CAS Number: 149697-16-5

€ 151.90 – € 606.70

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Product Description

Z-AAN-AMC, standard substrate for legumain (EC 3.4.22.34), was originally used for the plant enzyme and later to discover the mammalian form of the enzyme. Legumain may be a physiologic local regulator of human osteoclast (OCL) activity that can negatively modulate OCL.

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Inhibition of aggregation of amyloid peptides by beta-sheet breaker peptides and their binding affinity.

M.H.Viet et al., J Phys Chem B, 115, 7433 (2011)

Identification of human asparaginyl endopeptidase (legumain) as an inhibitor of osteoclast formation and bone resorption

S.J.Choi et al., J. Biol. Chem., 274, 27747 (1999)

Legumain forms from plants and animals differ in their specificity.

V.I.Rotari et al., Biol. Chem., 382, 953 (2001)

Carboxy terminal extended phytocystatins are bifunctional inhibitors of papain and legumain cysteine proteinases.

M.Martinez et al., FEBS Lett., 581, 2914 (2007)

Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.

M.A.Mathieu et al., Mol. Biochem. Parasitol., 121, 99 (2002)

The two cysteine endopeptidases of legume seeds: purification and characterization by use of specific fluorometric assays.

A.A.Kembhavi et al., Arch. Biochem. Biophys., 303, 208 (1993)

Colorimetric and fluorimetric microplate assays for legumain and a staining reaction for detection of the enzyme after electrophoresis.

H.T.Johansen et al., Anal. Biochem., 273, 278 (1999)

Pig kidney legumain: an asparaginyl endopeptidase with restricted specificity.

P.M.Dando et al., Biochem. J., 339, 743 (1999)

Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase.

J.-M.Chen et al., J. Biol. Chem., 272, 8090 (1997)

Molecular weight: 565.58

Sum Formula: C₂₈H₃₁N₅O₈

Storage Temperature: < -15°C

One Letter code: Z-AAN-AMC

Source: Synthetic

Old Product Number: I-1865

Substrates
Legumain

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