(D-Trp⁶)-LHRH

Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂

Product Number: 4033016

CAS Number: 57773-63-4

€ 88.80 – € 356.30

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Product Description

LHRH agonist used in the treatment of prostate cancer. Triptorelin decreases the secretion of LH and FSH. CAS-number (triptorelin acetate) 140194-24-7.

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Peptides in cancer research
Importance of early tumour exacerbation in patients treated with long acting analogues of gonadotrophin releasing hormone for advanced prostatic cancer.

A.S.Dutta, Drugs Future, 13, 43 (1988)

Effects of in vivo pretreatment with D-Trp-6-LH-RH on prolactin and LH secretion by pituitary glands in vitro.

J.Waxman et al., Br. Med. J., 291, 1387 (1985)

Combination of long-acting microcapsules of the D-tryptophan-6 analog of luteinizing hormone-releasing hormone with chemotherapy: investigation in the rat prostate cancer model.

I.Torres-Aleman et al., Peptides, 6, 993 (1985)

Radioimmunoassay for 6-D-tryptophan analog of luteinizing hormone-releasing hormone: measurement of serum levels after administration of long-acting microcapsule formulations.

A.V.Schally and T.W.Redding, Proc. Natl. Acad. Sci. USA, 82, 2498 (1985)

Luteinizing hormone-releasing hormone agonist triptorelin and antagonist cetrorelix inhibit EGF-induced c-fos expression in human gynecological cancers.

M.Mason-Garcia et al., Proc. Natl. Acad. Sci. USA, 82, 1547 (1985)

Gonadotropin-releasing hormone type II antagonists induce apoptotic cell death in human endometrial and ovarian cancer cells in vitro and in vivo.

C.Gründker et al., Gynecol. Oncol., 78, 194 (2000)

Radioimmunoassay of [D-Trp6]-luteinizing hormone-releasing hormone: its application to animal pharmacokinetic studies after single injection and long-acting formulation administration.

S.Fister et al., Cancer Res., 67, 1750 (2007)

D-Trp-6-luteinizing hormone-releasing hormone inhibits hyperprolactinemia in female rats.

E.Ezan et al., Regul. Pept., 14, 155 (1986)

Antiproliferative effects of the GnRH antagonist cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I receptor.

L.Debeljuk et al., Endocrinology, 116, 2227 (1985)

C.F.Heyns, Am. J. Cancer, 4, 169 (2005)

C.Gründker et al., Eur. J. Endocrinol., 151, 141 (2004)

Salt form: Acetate

Molecular weight: 1311.47

Chemical Formula: C₆₄H₈₂N₁₈O₁₃

Storage Temperature: < -15°C

Synonyms: (D-Trp⁶)-GnRH

One Letter code: pEHWSYwLRPG-NH₂

Source: Synthetic

Old Product Number: H-4075

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