Cholecystokinin Octapeptide (sulfated)

H-Asp-Tyr(SO₃H)-Met-Gly-Trp-Met-Asp-Phe-NH₂

Product Number: 4033010

CAS Number: 25126-32-3

€ 133.80 – € 535

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Product Description

CCK-8 exhibits various gastrointestinal effects as contraction of the gallbladder and stimulation of pancreatic secretion and gastrointestinal transit. In rats, CCK-8 facilitated the uptake of leptin from peripheral circulation to cerebrospinal fluid and its access to the hypothalamus.

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VIP/PACAP Peptides
Somatostatin in Alzheimer's disease and depression.

G.Bissette and B.Myers, Life Sci., 51, 1389 (1992)

A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin.

V.Cano et al., Br. J. Pharmacol., 154, 1009 (2008)

Coordinated gastric and sphincter motility evoked by intravenous CCK-8 as monitored by ultrasonomicrometry in rats.

D.W.Adelson et al., Am. J. Physiol. Gastrointest. Liver Physiol., 286, G321 (2004)

CCK-8 prevents the development of kindling and regulates the GABA and NPY expression in the hippocampus of pentylenetetrazole (PTZ)-treated adult rats.

P.Tirassa et al., Neuropharmacology, 48, 732 (2005)

Leptin-mediated hypothalamic pathway of cholecystokinin (CCK-8) to regulate body weight in free-feeding rats.

B.Merino et al., Endocrinology, 149, 1994 (2008)

Salt form: Ammonium

Molecular weight: 1143.29

Chemical Formula: C₄₉H₆₂N₁₀O₁₆S₃

Storage Temperature: < -15°C

Synonyms: Cholecystokinin (26-33) (sulfated)

Source: Synthetic

Old Product Number: H-2080

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