Ac-Cys-OH

Ac-Cys-OH

Product Number: 4031426

CAS Number: 616-91-1

€ 62.10 – € 249.30

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Product Description

NAC induced apoptosis in rat and human smooth muscle cells and serves as an efficient substrate for the rat liver microsomal glutathione transferase with 1-chloro-2,4-dinitrobenzene as second substrate. The conjugate with phenethyl isothiocyanate induces apoptosis predominantly in growth-promoted cells, which leads to the assumption that this conjugate inhibits lung carcinogenesis. Furthermore, NAC has been found to act as a specific inhibitor of TGF-β signaling targeting different components of the TGF-β signaling machinery.

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Xenopsin-related peptide generated in avian gastric extracts.

R.E.Carraway et al., Regul. Pept., 22, 303 (1988)

N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells.

Y.M.Yang et al., Cancer Res., 65, 8538 (2005)

Identification of N-acetylcysteine as a new substrate for rat liver microsomal glutathione transferase. A study of thiol ligands.

R.Weinander et al., J. Biol. Chem., 269, 71 (1994)

Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells.

J.-C.Tsai et al., J. Biol. Chem., 271, 3667 (1996)

The role of the thiol N-acetylcysteine in the prevention of tumor invasion and angiogenesis.

, Merck Index, 15th ed., No. 83, (2013)

N-acetyl-L-cysteine suppresses TGF-beta signaling at distinct molecular steps: the biochemical and biological efficacy of a multifunctional, antifibrotic drug.

M.Morini et al., Int. J. Biol. Markers, 14, 268 (1999)

S.K.Meurer et al., Biochem. Pharmacol., 70, 1026 (2005)

Molecular weight: 163.2

Chemical Formula: C₅H₉NO₃S

Storage Temperature: Room temperature

Synonyms: NAC

Old Product Number: E-3710

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