(D-Lys(nicotinoyl)¹,β-(3-pyridyl)-Ala³,3,4-dichloro-D-Phe⁵,Asn⁶,D-Trp⁷·⁹,Nle¹¹)-Substance P

H-D-Lys(nicotinoyl)-Pro-β-(3-pyridyl)-Ala-Pro-3,4-dichloro-D-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH₂

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Product Number: 4031291

CAS Number: 129176-97-2

€ 133.80 – € 535

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Product Description

Spantide II is even more potent as a substance P antagonist than spantide I and less effective in releasing histamine from mast cells. Of further advantage is the negligible neurotoxicity of spantide II.

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K+ channels as targets for specific immunomodulation.

K.G.Chandy et al., Trends Pharmacol. Sci., 25, 280 (2004)

Antinociceptive and substance P antagonistic effects of intrathecally injected spantide II in rat: no signs of motor impairment or neurotoxicity.

Z.Wiesenfeld-Hallin et al., Regul. Pept., 29, 1 (1990)

Comparison of spantide II and CP-96,345 for blockade of tachykinin-evoked contractions of smooth muscle.

R.Hakanson et al., Biochem. Biophys. Res. Commun., 178, 297 (1991)

Spantide II, an effective tachykinin antagonist having high potency and negligible neurotoxicity.

K.Folkers et al., Proc. Natl. Acad. Sci. USA, 87, 4833 (1990)

Salt form: Trifluoroacetate

Molecular weight: 1668.79

Chemical Formula: C₈₆H₁₀₄Cl₂N₁₈O₁₃

Storage Temperature: < -15°C

Synonyms: Spantide II

Source: Synthetic

Old Product Number: H-8310

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