Pepstatin A

Isovaleryl-Val-Val-Sta-Ala-Sta-OH

Product Number: 4031136

CAS Number: 26305-03-3

€ 107 – € 321

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Product Description

Pepstatin A (isovaleryl-pepstatin), a low molecular weight inhibitor of acid proteases, e.g. pepsin, renin, cathepsin D, and plasmepsin II. For the Plasmodium falciparum aspartyl protease plasmepsin II, Hill et al determined an IC₅₀ of 0.1 nM.

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p-Aminobenzamidine as a fluorescent probe for the active site of serine proteases.

S.A.Evans et al., J. Biol. Chem., 257, 3014 (1982)

Pepsin inhibition by a high specific activity radioiodinated derivative of pepstatin.

R.J.Workman and D.W.Burkitt, Arch. Biochem. Biophys., 194, 157 (1979)

THE STRUCTURE OF PEPSTATIN.

H.Umezawa et al., J. Antibiot., 23, 263 (1970)

Protease inhibitors produced by microorganisms.

H.Umezawa et al., J. Antibiot., 23, 259 (1970)

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=358710

H.Umezawa, Acta Biol. Med. Ger., 36, 1899 (1977)

A.M.Silva et al., Proc. Natl. Acad. Sci. USA, 93, 10034 (1996)

Molecular weight: 685.9

Sum Formula: C₃₄H₆₃N₅O₉

Storage Temperature: < -15°C

Source: Synthetic

Old Product Number: N-1125

Inhibitors
Cathepsin D
Chymase
Chymosin
Retropepsin
Kexin
Pepsin A
Renin
Protein-Glutamate Methylesterase
Cathepsin E
Lysosomal Pro-X Carboxypeptidase
Peptidyl-Dipeptidase Dcp
Yapsin 1
Gastricsin
Plasmepsin II
Napsin
Candidapepsin
HIV-2 Protease

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