Tachyplesin I

H-Lys-Trp-Cys-Phe-Arg-Val-Cys-Tyr-Arg-Gly-Ile-Cys-Tyr-Arg-Arg-Cys-Arg-NH₂ (Disulfide bonds between Cys³ and Cys¹⁶/Cys⁷ and Cys¹²)

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Product Number: 4030734

CAS Number: 118231-04-2

€ 401.30 – € 723.30

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Product Description

Tachyplesin I is an antimicrobial peptide originally detected in the extract of hemocytes from the Japanese horseshoe crab. It inhibits the growth of both Gramnegative and -positive bacteria and forms a complex with bacterial lipopolysaccharides. These results suggest that this peptide belongs to the family of arthropodous peptide antibiotics. Furthermore this peptide has been shown to have antiviral activity against vesicular stomatitis virus, influenza A virus and HIV-1.

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Introduction to Antimicrobial Peptides

Analysis of the mechanism for extracellular processing in the presentation of human immunodeficiency virus-1 envelope protein-derived peptide to epitope-specific cytotoxic T lymphocytes.

Y.Nakagawa et al., Immunology, 101, 76 (2000)

Antimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity.

T.Miyata et al., J. Biochem., 106, 663 (1989)

In Vitro Activity of the Limulus Antimicrobial Peptide Tachyplesin I on Marine Bivalve Pathogens

A.Morvan et al., J. Invertebr. Pathol., 69, 177 (1997)

Mode of action of an antimicrobial peptide, tachyplesin I, on biomembranes.

T.Katsu et al., Biol. Pharm. Bull., 16, 178 (1993)

Antimicrobial peptide, tachyplesin I, isolated from hemocytes of the horseshoe crab (Tachypleus tridentatus). NMR determination of the beta-sheet structure.

K.Kawano et al., J. Biol. Chem., 265, 15365 (1990)

Salt form: Trifluoroacetate

Molecular weight: 2263.78

Chemical Formula: C₉₉H₁₅₁N₃₅O₁₉S₄

Storage Temperature: < -15°C

One Letter code: KWCFRVCYRGICYRRCR-NH₂

Source: Synthetic

Old Product Number: H-1202

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