Cyclo(-Phe-Pro)

Cyclo(-Phe-Pro)

Product Number: 4029456

CAS Number: 3705-26-8

€ 142.30 – € 428

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Product Description

Cain et al. obtained an array of small molecule peptide mimetics targeting the melanocortin receptors from this diketopiperazine. Brauns et al. demonstrated that cyclo(Phe-Pro) inhibits the growth of HT-29, MCF-7 and HeLa cells and induces apoptosis in HT-29 colon cancer cells.

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Peptides in cancer research
Cyclic dipeptides in the induction of maturation for cancer therapy.

C.J.M.Graz et al., J. Pharm. Pharmacol., 52, 75 (2000)

Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors.

J.P.Cain et al., Bioorg. Med. Chem. Lett., 16, 5462 (2006)

Selected cyclic dipeptides inhibit cancer cell growth and induce apoptosis in HT-29 colon cancer cells.

S.C.Brauns et al., Anticancer Res., 24, 1713 (2004)

Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants.

R.Ortiz-Castro et al., Proc. Natl. Acad. Sci. USA, 108, 7253 (2011)

Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants.

R.Ortiz-Castro et al., Proc. Natl. Acad. Sci. USA, 108, 7253 (2011)

M.M.Bobylev et al., J. Agric. Food Chem., 44, 3960 (1996)

A.Trigos et al., Nat. Prod. Lett., 8, 199 (1996)

Molecular weight: 244.29

Chemical Formula: C₁₄H₁₆N₂O₂

Storage Temperature: < -15°C

Source: Synthetic

Old Product Number: G-4720

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