Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂
€ 249.30 – € 999.40
| Pack size available | 1mg, 5mg |
|---|
Please select pack size:
Product Description
The N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH₂ with a Lys yields a fluorogenic peptide with improved substrate properties. As compared to Mca-PLGL-Dpa-AR-NH₂, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate Mca-KPLGL-Dpa-AR-NH₂ for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased two- to ninefold and threefold, respectively, while those for gelatinases and matrilysin remain equally high.
| Substrates |
|---|
| Interstitial Collagenase |
| Gelatinase A |
| Stromelysin 1 |
| Matrilysin |
| Collagenase-2 |
| Gelatinase B |
| Collagenase-3 |
| Matrix Metalloproteinase-14 (MMP-14) |
| Matrix Metalloproteinase-2 (MMP-2) |
| Matrix Metalloproteinase-1 (MMP-1) |
| Matrix Metalloproteinase-7 (MMP-7) |
| Matrix Metalloproteinase-3 (MMP-3) |
| Matrix Metalloproteinase-8 (MMP-8) |
| Matrix Metalloproteinase-9 (MMP-9) |
| Matrix Metalloproteinase-13 (MMP-13) |
| Matrix Metalloproteinase-20 (MMP-20) |
| ADAM17 Endopeptidase |
