(Des-Gly¹⁰,D-Ser(tBu)⁶,Pro-NHEt⁹)-LHRH

Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt

Product Number: 4028150

CAS Number: 57982-77-1

CHF 112.40 – CHF 449.40

Custom/Bulk Quote

Pack size available	5mg, 25mg

Please select pack size:

Pack size available

Clear

Add to your inquiry

Product Description

Buserelin is a longer acting synthetic peptide analog of the naturally occurring gonadotropin-releasing hormone (GnRH/LHRH). Substitution of glycine in position 6 by D-serine and that of glycinamide in position 10 by ethylamide, leads to a nonapeptide with a significantly enhanced LHRH effect. The effects of buserelin on follicle-stimulating hormone (FSH) and luteinizing hormone (LH) release are approximately 20 to 170 times higher than those of natural LHRH. CAS Number (buserelin acetate): 68630-75-1.

ADS

ADS lookup

MSDS

MSDS lookup

Peptides in cancer research

Distribution and characterization of immunoreactive adrenomedullin in porcine tissue, and isolation of adrenomedullin [26-52] and adrenomedullin [34-52] from porcine duodenum.

Y.Ichiki et al., J. Biochem., 118, 765 (1995)

Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells.

Y.Wang et al., Eur. J. Endocrinol., 146, 447 (2002)

Buserelin in the treatment of prostatic cancer.

F.Roila, Biomed. Pharmacother., 43, 279 (1989)

Buserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical profile.

R.N.Brogden et al., Drugs, 39, 399 (1990)

Evidence for hormone-responsive cleavage of gonadotropin-releasing hormone by the plasma membrane of ovarian cancer cells.

, Merck Index, 15th ed., No. 1506, (2013)

Gonadotropin-releasing hormone analog repairs reduced endometrial cell apoptosis in endometriosis in vitro.

A.Imai et al., Int. J. Oncol., 20, 987 (2002)

Signalling and anti-proliferative effects mediated by gonadotrophin-releasing hormone receptors after expression in prostate cancer cells using recombinant adenovirus.

A.Imai et al., Am. J. Obstet. Gynecol., 182, 1142 (2000)

J.Franklin et al., J. Endocrinol., 176, 275 (2003)

Salt form: Acetate

Molecular weight: 1239.44

Chemical Formula: C₆₀H₈₆N₁₆O₁₃

Storage Temperature: < -15°C

Synonyms: Buserelin

Source: Synthetic

Old Product Number: H-4224

Country

Inquiry List