L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

Product Number: 4027911

CAS Number: 88321-09-9

€ 116.60 – € 464.40

Custom/Bulk Quote

Pack size available	1mg, 5mg

Please select pack size:

Pack size available

Clear

Add to your inquiry

Product Description

E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer’s disease animal models.

ADS

ADS lookup

MSDS

MSDS lookup

Amyloid Beta Peptides & Alzheimer's Disease

Inhibition of digestive trypsin-like proteases from larvae of several lepidopteran species by the diagnostic cysteine protease inhibitor E-64

C.Novillo et al., Insect Biochem. Mol. Biol., 27, 247 (1997)

Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases.

M.Tamai et al., Chem. Pharm. Bull., 35, 1098 (1987)

In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.

M.Tamai et al., J. Pharmacobio-Dyn., 9, 672 (1986)

E.J.Murray et al., Metabolism, 46, 1090 (1997)

Molecular weight: 342.44

Sum Formula: C₁₇H₃₀N₂O₅

Storage Temperature: < -15°C

Synonyms: L-trans-Epoxysuccinyl(OEt)-Leu-3-methylbutylamide

Old Product Number: N-1650

Inhibitors
Cathepsin H
Calpain
Cathepsin D
Cathepsin L
Calpain-2
Cathepsin B

Country

Inquiry List