Z-Phe-Tyr-aldehyde

Z-Phe-Tyr-aldehyde

Product Number: 4027130

CAS Number: 167498-29-5

€ 160.50 – € 481.50

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Product Description

Z-Phe-Tyrosinal is a potent and selective cathepsin L inhibitor. In the pit formation assay with unfractionated rat bone cells, 1.5 nM of Z-FY-CHO markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption. In ovariectomized mice, it suppressed at 2.5-10 mg/kg/day ip for four weeks bone weight loss dose-dependently.

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Calpain inhibitor MDL28170 modulates Abeta formation by inhibiting the formation of intermediate Abeta46 and protecting Abeta from degradation.

Y.Dong et al., FASEB J., 20, 331 (2006)

Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells.

A.Wille et al., Biol. Chem., 385, 665 (2004)

Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo.

J.-T.Woo et al., Eur. J. Pharmacol., 300, 131 (1996)

Molecular weight: 446.5

Sum Formula: C₂₆H₂₆N₂O₅

Storage Temperature: < -15°C

Synonyms: Z-FY-CHO

Source: Synthetic

Old Product Number: N-1540

Inhibitors
Cathepsin B
Cathepsin L
Calpain

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