Decanoyl-Arg-Val-Lys-Arg-chloromethylketone

Decanoyl-Arg-Val-Lys-Arg-chloromethylketone

Product Number: 4026850

CAS Number: 150113-99-8

CHF 786.50 – CHF 3,147.90

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Product Description

Dec-RVKR-CMK binds to the catalytic site of furin and therefore acts as a potent inhibitor of cleavage and fusion activity of viral glycoproteins, as well as virus replication. Furthermore it was demonstrated that Dec-RVKR-CMK decreased the production of β-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Apart from furin, Dec-RVKR-CMK also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).

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Immunosuppressive activity of hymenistatin I.

M.Cebrat et al., Peptides, 17, 191 (1996)

Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2.

J.L.Wheatley and T.Holyoak, Proc. Natl. Acad. Sci. USA, 104, 6626 (2007)

Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.

A.Stieneke-Gröber et al., EMBO J., 11, 2407 (1992)

Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160.

S.Hallenberger et al., Nature, 360, 358 (1992)

The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells.

S.Hallenberger et al., J. Virol., 71, 1036 (1997)

Inhibition of proteolytic activation of influenza virus hemagglutinin by specific peptidyl chloroalkyl ketones.

W.Garten et al., Virology, 172, 25 (1989)

Activated isoforms of MMP-2 are induced in U87 human glioma cells in response to beta-amyloid peptide.

S.Deb et al., J. Neurosci. Res., 55, 44 (1999)

Inhibition of convertase-related processing of proendothelin-1.

J.-B.Denault et al., J. Cardiovasc. Pharmacol., 26 (Suppl.3), S47 (1995)

Processing of proendothelin-1 by human furin convertase.

J.-B.Denault et al., FEBS Lett., 362, 276 (1995)

Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2.

J.L.Wheatley and T.Holyoak, Proc. Natl. Acad. Sci. USA, 104, 6626 (2007)

Salt form: Trifluoroacetate

Molecular weight: 744.42

Sum Formula: C₃₄H₆₆ClN₁₁O₅

Storage Temperature: < -15°C

Synonyms: Dec-RVKR-CMK

Source: Synthetic

Old Product Number: N-1505

Inhibitors
Furin
Kexin
Matrix Metalloproteinase-2 (MMP-2)
Site-1 Protease
Flavivirin

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