Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde

Product Number: 4026408

CAS Number: 158442-41-2

€ 133.80

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Product Description

Z-IE(OtBu)AL-CHO is an inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. It is the first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors may be considered as potential anti-neoplastic agents.

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Peptides in Cosmetics: Pioneering partner for cosmetic peptides
Structure-activity relationships of an anti-HIV peptide, T22.

H.Tamamura et al., Biochem. Biophys. Res. Commun., 205, 1729 (1994)

Apoptosis induced in L1210 leukaemia cells by an inhibitor of the chymotrypsin-like activity of the proteasome.

C.Wojcik et al., Apoptosis, 2, 455 (1997)

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

E.B.-M.Traenckner et al., EMBO J., 13, 5433 (1994)

Molecular weight: 618.77

Sum Formula: C₃₂H₅₀N₄O₈

Storage Temperature: < -15°C

Synonyms: Proteasome Inhibitor I

Source: Synthetic

Old Product Number: C-3900

Inhibitors
Multicatalytic Endopeptidase Complex
Proteasome Endopeptidase Complex

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