Z-Asp-2,6-dichlorobenzoyloxymethylketone

Z-Asp-2,6-dichlorobenzoyloxymethylketone

Product Number: 4026406

CAS Number: 153088-73-4

€ 312.40 – € 623.80

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Product Description

Z-Asp-CH2-DCB, inhibitor of caspase-1 (ICE) has been found to prevent apoptosis caused by various types of cytotoxic agents. Such a modulation of apoptotic cell death caused by antitumor agents might offer new antitumor strategies.

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Peptides in cancer research
Interaction of antistasin-related peptides with factor Xa: identification of a core inhibitory sequence.

N.Ohta et al., Thromb. Haemost., 72, 825 (1994)

Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells.

U.K.Messmer et al., Kidney Int., 55, 2322 (1999)

Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells.

T.Mashima et al., Biochem. Biophys. Res. Commun., 209, 907 (1995)

Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation.

T.Krakauer, Clin. Diagn. Lab Immunol., 11, 621 (2004)

Molecular weight: 454.26

Sum Formula: C₂₀H₁₇Cl₂NO₇

Storage Temperature: < -15°C

Synonyms: Z-Asp-CH₂-DCB

Source: Synthetic

Old Product Number: N-1445

Inhibitors
Caspase-1 (ICE)

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