(Des-Gly)-Glutathione-monoethyl ester (reduced)

H-Glu(Cys-OEt)-OH

Product Number: 4026208

CAS Number: 114627-30-4

€ 392.70 – € 1,178.10

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Product Description

γ-GCE has been shown to be much more easily transported into isolated rat hepatocytes than glutathione. Within the cells it could be converted into reduced glutathione. Therefore it could – better than glutathione – prevent immunological cell injury in isolated rat hepatocytes treated with anti-rat liver plasma membrane rabbit antiserum. γ-GCE may help to reduce oxidative stress in various biological systems by promoting the biosynthesis of glutathion. For this reason, administration of GCEE and N-acetyl-cysteine (NAC) was discussed as a potential therapeutic approach for Alzheimer disease.

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Amyloid Beta Peptides & Alzheimer's Disease

The core Alzheimer's peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?

H.Han et al., Chemistry and Biology, 2, 163 (1995)

Elevation of glutathione as a therapeutic strategy in Alzheimer disease.

C.B.Pocernich and D.A. Butterfield, Biochim. Biophys. Acta, 1822, 625 (2012)

Preventive effect of gamma-glutamylcysteinylethyl ester on immunological cell injury in isolated rat hepatocytes with anti-rat liver plasma membrane antiserum treatment.

K.Nishida et al., Res. Commun. Chem. Pathol. Pharmacol., 82, 49 (1993)

Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain.

G.Joshi et al., J. Neurosci. Res., 85, 497 (2007)

Molecular weight: 278.33

Chemical Formula: C₁₀H₁₈N₂O₅S

Storage Temperature: < -15°C

Synonyms: γ-GCE

Source: Synthetic

Old Product Number: G-4430

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