α-Synuclein (61-95) (human)

H-Glu-Gln-Val-Thr-Asn-Val-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-Gln-Lys-Thr-Val-Glu-Gly-Ala-Gly-Ser-Ile-Ala-Ala-Ala-Thr-Gly-Phe-Val-OH

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Product Number: 4026207

CAS Number: 154040-19-4

CHF 212.90 – CHF 383.10

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Product Description

The 35 amino acid peptide NAC (α-synuclein (61-95)) has originally been isolated from the insoluble core of Alzheimer’s disease (AD) amyloid plaque. The sequence corresponds to a fragment of a 140 amino acid precursor known as NACP or α-synuclein and was found to form amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.

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Amyloid Beta Peptides & Alzheimer's Disease
The synergy peptide PHSRN and the adhesion peptide RGD mediate cell adhesion through a common mechanism.

Y.Feng and M.Mrksich, Biochemistry, 43, 15811 (2004)

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.

J.Kakimura et al., FASEB J., 16, 601 (2002)

Toxicity of non-abeta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils.

A.M.Bodles et al., Eur. J. Biochem., 276, 2168 (2000)

Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic.

A.Iwai et al., Biochemistry, 34, 10139 (1995)

Salt form: Trifluoroacetate

Molecular weight: 3260.65

Chemical Formula: C₁₄₁H₂₃₅N₃₉O₄₉

Storage Temperature: < -15°C

Synonyms: Non-Aβ Component of Alzheimer's Disease Amyloid

One Letter code: EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFV

Source: Synthetic

Old Product Number: H-2598

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