Cyclo(-Arg-Gly-Asp-D-Phe-Val)

Cyclo(-Arg-Gly-Asp-D-Phe-Val)

Product Number: 4026200

CAS Number: 137813-35-5

€ 88.80 – € 356.30

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Product Description

c(RGDfV) is a potent inhibitor of cell adhesion. It inhibited tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats provided the first evidence of its utility in the amelioration of ischemic acute renal failure. c(RGDfV) inhibited tubular obstruction by preventing cell-cell adhesion. Hammes et al. showed that the cyclopeptide can also be used to prevent retinal neovascularization. c(RGDfV) binds to αvβ3 receptors.

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Peptides in cancer research
Involvement of arginine vasotocin in reproductive events in the male newt Cynops pyrrhogaster.

F.Toyoda et al., Horm. Behav., 44, 346 (2003)

Cyclic RGD peptides ameliorate ischemic acute renal failure in rats.

E.Noiri et al., Kidney Int., 46, 1050 (1994)

Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization.

H.-P.Hammes et al., Nat. Med., 2, 529 (1996)

Salt form: Trifluoroacetate

Molecular weight: 574.64

Chemical Formula: C₂₆H₃₈N₈O₇

Storage Temperature: < -15°C

Synonyms: c(RGDfV)

One Letter code: c(RGDfV)

Source: Synthetic

Old Product Number: H-2574

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