(Glu²)-TRH

Pyr-Glu-Pro-NH₂

Product Number: 4026102

CAS Number: 85541-78-2

€ 160.50 – € 643.10

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Product Description

Fertilization-promoting peptide (FPP), a TRH analog, was previously purified and characterized from both rabbit prostate and human semen. Nanomolar concentrations of this peptide have been shown to enhance capacitation of mouse epididymal spermatozoa with a concomitant increase in fertilizing ability. It was also detected in the thyroid gland. According to a study of Nguyen et al. Pyr-Glu-Pro-NH₂ opposes the cholinergic effect of TRH in the mammalian CNS: Co-perfusion with an equivalent of TRH in the rat hippocampus resulted in a significant attenuation of TRH-induced acetylcholine release.

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Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms.

M.L.Dubocovich et al., FASEB J., 12, 1211 (1998)

Peptides related to thyrotrophin-releasing hormone (TRH) in human prostate and semen.

S.M.Cockle et al., Biochim. Biophys. Acta, 1227, 60 (1994)

The thyrotropin-releasing hormone-like peptides pGlu-Phe-Pro amide and pGlu-Glu-Pro amide increase plasma triiodothyronine levels in the mouse; the activity is sensitive to testosterone.

A.Cremades et al., Eur. J. Pharmacol., 358, 63 (1998)

Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2.

K.Prokai-Tatrai et al., Bioorg. Med. Chem. Lett., 13, 1011 (2003)

Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain: an in vivo microdialysis study.

V.Nguyen et al., Neurosci. Lett., 415, 64 (2007)

Identification of the human seminal TRH-like peptide pGlu-Phe-Pro-NH2 in normal human prostate.

P.J.Gkonos et al., Peptides, 15, 1281 (1994)

Stimulating effect of pyroglutamylglutamylprolineamide, a prostatic, TRH-related tripeptide, on mouse sperm capacitation and fertilizing ability in vitro.

C.M.Green et al., Mol. Reprod. Dev., 38, 215 (1994)

Molecular weight: 354.36

Chemical Formula: C₁₅H₂₂N₄O₆

Storage Temperature: < -15°C

Synonyms: Fertilization-Promoting Peptide

One Letter code: pEEP-NH₂

Source: Synthetic

Old Product Number: H-2464

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