ω-Conotoxin MVIIA

H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH₂ (Disulfide bonds between Cys¹ and Cys¹⁶/Cys⁸ and Cys²⁰/Cys¹⁵ and Cys²⁵)

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Product Number: 4025279

CAS Number: 107452-89-1

€ 401.30 – € 713.70

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Product Description

ω-Conotoxin MVIIA, originally isolated from the venom of the fish-hunting cone snail Conus magus, is a blocker of voltage-sensitive Ca²⁺ channels in neurons. The peptide has been used to identify different Ca²⁺ channel subtypes in amphibian brain.

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An efficient conversion of the carboxylic group of N-Fmoc alpha-amino acids/peptide acids into N-formamides employing isocyanates as key intermediates.

N.S.Sudarshan et al., J. Org. Chem., 72, 9804 (2007)

Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom.

B.M.Olivera et al., Biochemistry, 26, 2086 (1987)

Different omega-conotoxins mark the development of Swiss Webster mouse cortex suggesting N-type voltage sensitive calcium channel subtypes.

J.R.Abbott and M.J.Litzinger, Int. J. Devl Neurosci., 12, 43 (1994)

Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom.

B.M.Olivera et al., Biochemistry, 26, 2086 (1987)

Different omega-conotoxins mark the development of Swiss Webster mouse cortex suggesting N-type voltage sensitive calcium channel subtypes.

J.R.Abbott and M.J.Litzinger, Int. J. Devl Neurosci., 12, 43 (1994)

Effects of diverse omega-conopeptides on the in vivo release of glutamic and gamma-aminobutyric acids.

R.Newcomb and A.Palma, Brain Res., 638, 95 (1994)

Molecular weight: 2639.17

Chemical Formula: C₁₀₂H₁₇₂N₃₆O₃₂S₇

Storage Temperature: < -15°C

One Letter code: CKGKGAKCSRLMYDCCTGSCRSGKC-NH₂

Source: Synthetic

Old Product Number: H-8210

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