Exenatide

H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂

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Product Number: 4019602

CAS Number: 141758-74-9

CHF 311.40 – CHF 535

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Product Description

Exendin-4 (exenatide), originally isolated from Heloderma suspectum venom, differs from exendin-3 by only 2 N-terminal amino acid substitutions. This polypeptide causes an increase in acinar cAMP without stimulating amylase release. Exendin-4 and glucagon-like peptide 1 (7-36) amide bind with similar affinity to the glucagon-like peptide 1 receptor. Moreover, exendin-4 is also considered for clinical use in the treatment of type 2 diabetes.

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Diabetes Peptides
Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease.

F.Dick and M.Schwaller, Peptides 1994, Proceedings of the 23rd European Peptide Symposium, Braga/Portugal, p. 240, H.L.S.Maya, ed., Escom, Leiden, (1995)

Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis.

G.Bertilsson et al., J. Neurosci. Res., 86, 326 (2008)

Exenatide. Amylin/Eli Lilly.

M.Marzioni et al., Gut, 58, 990 (2009)

Exenatide and the treatment of patients with Parkinson's disease.

N.Giannoukakis, Curr Opin Investig Drugs , 4, 459 (2003)

Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus.

I.Aviles-Olmos et al., J. Clin Invest., 123, 2730 (2013)

The glucagon-like peptides: a double-edged therapeutic sword?

L.Brunetti et al., Peptides, 29, 1377 (2008)

Stable expression of the rat GLP-I receptor in CHO cells: activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin-4, and exendin(9-39).

T.Perry and N.H.Greig, Trends Pharmacol. Sci., 24, 377 (2003)

H.C.Fehmann et al., Peptides, 15, 453 (1994)

Salt form: Acetate

Molecular weight: 4186.63

Chemical Formula: C₁₈₄H₂₈₂N₅₀O₆₀S

Storage Temperature: < -15°C

Synonyms: Exendin-4

One Letter code: HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH₂

Source: Synthetic

Old Product Number: H-8730

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