Peptide YY (3-36) (human)

H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH₂

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Product Number: 4018880

CAS Number: 123583-37-9

€ 178.70 – € 312.40

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Product Description

PYY (3-36), a Y2 receptor agonist, is released from the body’s gastrointestinal tract in proportion to caloric intake. It has been shown that peripheral injection of PYY (3-36) in rats inhibited food intake and reduced weight gain. In addition, infusion of PYY (3-36) in humans significantly decreased appetite and reduced food intake by 33% over 24h, which suggests that PYY (3-36) has a role in ‘longer term’ regulation of food intake. Thus, the PYY (3-36) may represent a lead compound for the development of drugs for the treatment of obesity.

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Diabetes Peptides
Rapid alterations in the plasma membrane structure of macrophages stimulated with bacterial lipopeptides.

B.Uhl et al., Eur. J. Cell Biol., 58, 90 (1992)

Peptide YY(3-36) inhibits both anorexigenic proopiomelanocortin and orexigenic neuropeptide Y neurons: implications for hypothalamic regulation of energy homeostasis.

C.Acuna-Goycolea and A.N.van den Pol, J. Neurosci., 25, 10510 (2005)

Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actions.

G.H.Ballantyne, Obes. Surg., 16, 651 (2006)

Reversible PEGylation of peptide YY3-36 prolongs its inhibition of food intake in mice.

Y.Shechter et al., FEBS Lett., 579, 2439 (2005)

Inhibition of food intake in obese subjects by peptide YY3-36.

R.L.Batterham et al., N. Engl. J. Med., 349, 941 (2003)

Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice.

I.G.Halatchev and R.D.Cone, Cell Metab., 1, 159 (2005)

A new molecular form of PYY: structural characterization of human PYY(3-36) and PYY(1-36).

G.A.Eberlein et al., Peptides, 10, 797 (1989)

Gut hormone PYY(3-36) physiologically inhibits food intake.

R.L.Batterham et al., Nature, 418, 650 (2002)

Salt form: Trifluoroacetate

Molecular weight: 4049.52

Chemical Formula: C₁₈₀H₂₇₉N₅₃O₅₄

Storage Temperature: < -15°C

Synonyms: PYY (3-36) (human)

One Letter code: IKPEAPGEDASPEELNRYYASLRHYLNLVTRQRY-NH₂

Source: Synthetic

Old Product Number: H-8585

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