Z-Leu-Val-Gly-diazomethylketone

Z-Leu-Val-Gly-diazomethylketone

Product Number: 4016615

CAS Number: 119670-30-3

CHF 169.10 – CHF 505

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Product Description

The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication. Irreversible inhibitor of streptopain.

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Introduction to Antimicrobial Peptides
Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant.

A.M.Di Pietra et al., Chromatographia, 30, 215 (1990)

Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus.

K.Berggren et al., Bioorg. Med. Chem., 17, 3463 (2009)

Streptococcal cysteine proteinase releases kinins: a virulence mechanism.

L.Björck et al., J. Virol., 64, 941 (1990)

Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction.

H.Herwald et al., J. Exp. Med., 184, 665 (1996)

M.J.Frame et al., Parasitology, 121, 367 (2000)

Molecular weight: 445.52

Sum Formula: C₂₂H₃₁N₅O₅

Storage Temperature: < -15°C

One Letter code: Z-LVG-DMK

Source: Synthetic

Old Product Number: C-3455

Inhibitors
Streptopain

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