µ-Conotoxin GIIIB

H-Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH₂ (Disulfide bonds between Cys³ and Cys¹⁵/Cys⁴ and Cys²⁰/Cys¹⁰ and Cys²¹)

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Product Number: 4016344

CAS Number: 140678-12-2

€ 535 – € 892.40

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Product Description

This strongly basic µ-conotoxin from the venom of Conus geographus is highly effective in blocking sodium channels in vertebrate skeletal muscle, thereby preventing the propagation of muscle action potentials.

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ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.

C.M.Haynes et al., Dev. Cell, 13, 467 (2007)

Solution synthesis of mu-conotoxin GIIIB: optimization of the oxidative folding reaction.

L.J.Cruz et al., J. Toxicol. Toxin Rev., 4, 107 (1985)

Use of geographutoxin II (mu-conotoxin) for the study of neuromuscular transmission in mouse.

S.Kubo et al., Pept. Res., 6, 66 (1993)

Peptide toxins from venomous Conus snails.

S.J.Hong and C.C.Chang, Br. J. Pharmacol., 97, 934 (1989)

W.R.Gray et al., Annu. Rev. Biochem., 57, 665 (1988)

Molecular weight: 2640.21

Chemical Formula: C₁₀₁H₁₇₅N₃₉O₃₀S₇

Storage Temperature: < -15°C

Synonyms: Geographutoxin II (GTXII)

Source: Synthetic

Old Product Number: H-9015

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