(D-Ala¹)-Peptide T amide

H-D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH₂

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Product Number: 4015906

CAS Number: 106362-34-9

€ 214 – € 857.10

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Product Description

Potent analog of peptide T. DAPTA (aSTTTNYT-amide) showed a strong anti-HIV 1 activity in monocytes/macrophages, the peptide inhibits the entry of the virus.

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Muramyl peptides: immunomodulators, sleep factors, and vitamins.

A.Adam and E.Lederer, Med. Res. Rev., 4, 111 (1984)

Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors.

M.R.Ruff et al., Curr. HIV Res., 1, 51 (2003)

CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis. Relationship to vasoactive intestinal polypeptide.

M.R.Ruff et al., FEBS Lett., 211, 17 (1987)

Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA).

M.T.Polianova et al., Antiviral Res., 67, 83 (2005)

Antiviral and immunological benefits in HIV patients receiving intranasal peptide T (DAPTA).

M.T.Polianova et al., Peptides, 24, 1093 (2003)

Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells.

M.Pollicita et al., Antivir. Chem. Chemother., 18, 285 (2007)

Molecular weight: 856.89

Chemical Formula: C₃₅H₅₆N₁₀O₁₅

Storage Temperature: < -15°C

Synonyms: DAPTA

One Letter code: aSTTTNYT-NH₂

Source: Synthetic

Old Product Number: H-5935

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