Boc-Cys(NPys)-OH

Boc-Cys(NPys)-OH

Product Number: 4014705

CAS Number: 76880-29-0

CHF 134.80 – CHF 2,159.30

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Product Description

Npys allows site-directed disulfide bond formation, as it is cleaved by thiols. Galande and Spatola obtained disulfide heterodimers of peptides via coupling Boc-Cys(NPys)-OH together with Fmoc-Cys(Mmt)-OH to MBHA-resin followed by Mmt removal with 1% TFA in dichloromethane. Mourier et al. used BCNP for the identification of T-cell epitopes in Cys and/or Cyt-containing proteins.

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The melanocortin 1, 3, 4 or 5 receptors do not have a binding epitope for ACTH beyond the sequence of alpha-MSH.

H.B.Schiöth et al., J. Endocrinol. , 155, 73 (1997)

Use of the Npys thiol protection in solid phase peptide synthesis. Application to direct peptide-protein conjugation through cysteine residues.

F.Albericio et al., Int. J. Pept. Protein Res., 34, 124 (1989)

Boc-Cys(Npys)-OH (BCNP): an appropriate reagent for the identification of T cell epitopes in cystine and/or cysteine-containing proteins.

G.Mourier et al., J. Immunol. Methods, 171, 65 (1994)

Solid-phase synthesis of disulfide heterodimers of peptides.

A.K.Galande and A.F.Spatola, Org. Lett., 5, 3431 (2003)

Molecular weight: 375.43

Chemical Formula: C₁₃H₁₇N₃O₆S₂

Storage Temperature: < -15°C

Synonyms: BCNP

Old Product Number: A-2825

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