(Sar⁹,Met(O₂)¹¹)-Substance P

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O₂)-NH₂

Product Number: 4013867

CAS Number: 110880-55-2

CHF 89.90 – CHF 360.60

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Product Description

This NK-1 receptor agonist exhibits the highest selectivity for NK-1 receptors in various bioassays. It evokes a concentration-dependent increase in mucus secretion and is much more potent than substance P (EC₅₀= 1.7 · 10-⁶M).

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Unique amino terminal structure of rat little gastrin.

J.R.Reeve, Jr. et al., Peptides, 2, 453 (1981)

Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal.

F.Nieuwmeyer et al., J. Pharmacol. Exp. Ther., 317, 439 (2006)

Tachykinin control of ferret airways: mucus secretion, bronchoconstriction and receptor mapping.

S.Meini et al., Neuropeptides, 24, 81 (1993)

Multiple neurokinin receptors: Recent developments.

R.Quirion and T.V.Dam, Regul. Pept., 22, 18 (1988)

E.Cellier et al., Br. J. Pharmacol., 127, 717 (1999)

Molecular weight: 1393.68

Chemical Formula: C₆₄H₁₀₀N₁₈O₁₅S

Storage Temperature: < -15°C

Source: Synthetic

Old Product Number: H-9410

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