Calcitonin C-Terminal Flanking Peptide (human)

H-Asp-Met-Ser-Ser-Asp-Leu-Glu-Arg-Asp-His-Arg-Pro-His-Val-Ser-Met-Pro-Gln-Asn-Ala-Asn-OH

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Product Number: 4013739

CAS Number: 85916-47-8

€ 312.40

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Product Description

Katacalcin, a potent plasma calcium-lowering peptide, also called C-procalcitonin or PDN-21, flanks calcitonin on the C-terminal side within the human calcitonin precursor. Katacalcin specifically binds to the calcitonin receptor of CD14⁺ peripheral blood mononuclear cells.

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Peptides in cancer research

Medullary thyroid carcinomas secrete a noncalcitonin peptide corresponding to the carboxyl-terminal region of preprocalcitonin.

P.Fermlund and L.Josefsson, Science, 177, 173 (1972)

A second plasma calcium-lowering peptide from the human calcitonin precursor.

B.A.Roos et al., J. Clin. Endocrinol. Metab., 56, 802 (1983)

Involvement of cyclic adenosine monophosphate-dependent protein kinase A and pertussis toxin-sensitive G proteins in the migratory response of human CD14+ mononuclear cells to katacalcin.

I.MacIntyre et al., Nature, 300, 460 (1982)

Katacalcin: a new plasma calcium-lowering hormone.

N.C.Kaneider et al., J. Bone Miner. Res., 17, 1872 (2002)

C.J.Hillyard et al., Lancet, 1, 846 (1983)

Salt form: Trifluoroacetate

Molecular weight: 2436.63

Chemical Formula: C₉₇H₁₅₄N₃₄O₃₆S₂

Storage Temperature: < -15°C

Synonyms: Katacalcin

One Letter code: DMSSDLERDHRPHVSMPQNAN

Source: Synthetic

Old Product Number: H-2050

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