Product Number: 4010438

CAS Number: 76721-89-6

CHF 281.40CHF 843.20

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Product Description

Potent and specific inhibitor of neprilysin with antinociceptive activity. Thiorphan is cleaved by peptidylglycine α-amidating monooxygenase yielding 2-benzyl-3-mercaptopropionamide.

J.Kaiser et al., Org. Biomol. Chem., 3, 3435 (2005)

B.P.Roques and A.Beaumont, Trends Pharmacol. Sci., 11, 245 (1990)

D.A.Evans et al., J. Org. Chem., 50, 1830 (1985)

I.Dolev and D.M.Michaelson, Proc. Natl. Acad. Sci. USA, 101, 13909 (2004)

Molecular weight: 253.32

Sum Formula: C₁₂H₁₅NO₃S

Storage Temperature: < -15°C

Synonyms: (DL-3-Mercapto-2-benzylpropanoyl)-Gly-OH

Old Product Number: N-1195

Membrane Metalloendopeptidase


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