(D-Trp⁷,Ala⁸,D-Phe¹⁰)-α-MSH (6-11) amide

H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂

Product Number: 4008401

CAS Number: 87616-84-0

€ 88.80 – € 356.30

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Product Description

In search of competitive α-MSH antagonists, the hexapeptide GHRP-6 has been recognized as a selective inhibitor of α-MSH activity in the frog skin bioassay. It is identical in sequence with a growth hormone-releasing peptide analog, (His¹,Lys⁶)-GHRP, which selectively releases GH in vitro and in a wide variety of species in vivo. GHRP-6 also acts as a functional antagonist of somatostatin in the somatotrope cells.

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Diabetes Peptides
Lysinoalanine as a metal chelator. An implication for toxicity.

R.Hayashi, J. Biol. Chem., 257, 13896 (1982)

Binding of a growth hormone releasing hexapeptide to specific hypothalamic and pituitary binding sites.

E.E.Codd et al., Neuropharmacology, 28, 1139 (1989)

Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in rats, dogs and monkeys.

R.F.Walker et al., Life Sci., 47, 29 (1990)

Discovery and structure-activity relationships of novel alpha-melanocyte-stimulating hormone inhibitors.

T.K.Sawyer et al., Pept. Res., 2, 140 (1989)

Effect of D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2 (KP-102) on GH secretion in urethan-anesthetized rats.

H.Sawada et al., Regul. Pept., 53, 195 (1994)

Arginine enhances the growth hormone-releasing activity of a synthetic hexapeptide (GHRP-6) in elderly but not in young subjects after oral administration.

E.Ghigo et al., J. Endocrinol. Invest., 17, 157 (1994)

Molecular weight: 873.03

Chemical Formula: C₄₆H₅₆N₁₂O₆

Storage Temperature: < -15°C

Synonyms: GHRP-6

One Letter code: HwAWfK-NH₂

Source: Synthetic

Old Product Number: H-9990

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