H-6-Diazo-5-oxo-Nle-OH

H-6-Diazo-5-oxo-Nle-OH

Product Number: 4006579

CAS Number: 157-03-9

€ 214 – € 857.10

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Product Description

L-DON, which corresponds to Glu γ-diazomethyl ketone, inactivates rat renal phosphate-dependent glutaminase and is active against various tumor systems. Irreversible inhibitor of γ-glutamyl transferase (γ-GT).

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Peptides in cancer research
The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial.

R.Freeman et al., Neurology, 10, 2151 (1999)

Inactivation of rat renal phosphate-dependent glutaminase with 6-diazo-5-oxo-L-norleucine. Evidence for interaction at the glutamine binding site.

R.A.Shapiro et al., J. Biol. Chem., 254, 2835 (1979)

Molecular weight: 171.16

Sum Formula: C₆H₉N₃O₃

Storage Temperature: < -15°C

Synonyms: L-DON

Old Product Number: F-1510

Inhibitors
γ-Glutamyltransferase
Glutamate Synthase (NADH)
Amidophosphoribosyltransferase
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
Phosphoribosylformylglycinamidine Synthase
Glutaminase

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